| Informacje o amulospcva |
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08-16-2022 |
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Reputation
| Dodatkowe informacje o amulospcva |
| Bio: |
RNA suppresses NusA from binding to enzyme
It is known that the nucleosome's a-CTD inhibits the activity of NusA, which is needed to bind to RNA. The a-CTD is situated near the 3' stop of your nascent transcript and interacts with the nut-website RNA. Therefore, NusA prevents the nascent RNA from studying throughout the nascent transcript. This conversation involving NusA and RNA polymerase is important to regulate transcription.
The carboxy-terminal region of NusA is required for NusA's purpose in termination. This region also serves as a binding website for RNA. Some extent mutation during the carboxy-terminal region enhances antitermination as a result of NusA. Having said that, the deletion of the a-CTD stops NusA from stimulating termination in vitro. Hence, the carboxy-terminal inhibitory domain of NusA might be important for the antitermination of RNA.
A mix of nusA, rho, and nusG mutations was synthetically lethal. Nonetheless, lethality was suppressed when nucleoid protein H-NS was expressed from the cells. For that reason, NusA is necessary for variable-dependent transcription termination and is critical in producing a spectrum of termination efficiencies, starting from polarity to lethality. https://www.zenearth.com |
| Sex: |
Male |
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