| Informacje o seannadlmj |
| Dołączył: |
08-12-2022 |
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Reputation
| Dodatkowe informacje o seannadlmj |
| Bio: |
RNA suppresses NusA from binding to enzyme
It is thought which the nucleosome's a-CTD inhibits the activity of NusA, which is needed to bind to RNA. The a-CTD is located near the three' close with the nascent transcript and interacts Along with the nut-web page RNA. Subsequently, NusA stops the nascent RNA from reading from the nascent transcript. This conversation among NusA and RNA polymerase is critical to control transcription.
The carboxy-terminal location of NusA is needed for NusA's operate in termination. This area also serves as being a binding web site for RNA. Some extent mutation from the carboxy-terminal region enhances antitermination by NusA. On the other hand, the deletion with the a-CTD prevents NusA from stimulating termination in vitro. As a result, the carboxy-terminal inhibitory area of NusA might be important for the antitermination of RNA.
A mix of nusA, rho, and nusG mutations was synthetically lethal. Nevertheless, lethality was suppressed when nucleoid protein H-NS was expressed during the cells. For that reason, NusA is needed for component-dependent transcription termination which is critical in generating a spectrum of termination efficiencies, starting from polarity to lethality. https://www.zenearth.com |
| Sex: |
Male |
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